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Gastrointestinal distension by ISF significantly reduced short-term food intake without aversive behavior, and this effect was significantly attenuated by pretreatment with GLP-1R antagonist or chemical ablation of vagal sensory neurons (Fig

Importantly, surface-agnostic in this context refers to a topography-preserving physicochemical reactivation principle rather than equivalent levels of biologic or clinical evidence across all materials and outcomes

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